姓  名:
李健
職  稱(chēng):
研究員 博導(dǎo)
研究領(lǐng)域:
人類(lèi)強(qiáng)化學(xué)習(xí)和決策的神經(jīng)機(jī)制
聯(lián)系電話(huà):
+86 10 62767123(O)
通信地址:
北京大學(xué)王克楨樓 100080
電子郵件:
[email protected]

李健,男,現(xiàn)為北京大學(xué)心理與認(rèn)知科學(xué)學(xué)院研究員?;貒?guó)前于紐約大學(xué)心理系任職研究科學(xué)家。2000年由南京大學(xué)獲得理學(xué)學(xué)士學(xué)位,2005年獲得2007年貝勒醫(yī)學(xué)院獲得神經(jīng)生物學(xué)博士學(xué)位,學(xué)習(xí)期間獲得全額獎(jiǎng)學(xué)金, 2010年獲得紐約大學(xué)斯特恩 (Stern) 商學(xué)院工商管理學(xué)碩士 (MBA) 學(xué)位。李健博士于 2005年獲得 John Merck Foundation贊助的在普林斯頓大學(xué)的“旅行基金”,同年獲得布朗基金 (Brown Foundation) 獎(jiǎng)學(xué)金,2006年獲得國(guó)家教育部頒發(fā)的“海外自費(fèi)留學(xué)生獎(jiǎng)學(xué)金”,2011年獲得國(guó)際神經(jīng)生物學(xué)協(xié)會(huì)和格魯博基金會(huì) (Gruber Foundation) 頒發(fā)的“格魯博國(guó)際神經(jīng)生物學(xué)研究獎(jiǎng)”,同年獲得美國(guó)國(guó)家藥物成癮研究所(NIDA)的“研究旅行基金”, 2014年獲得求是基金會(huì)“杰出青年學(xué)者獎(jiǎng)”。

李健博士現(xiàn)擔(dān)任Cognitive, Affective & Behavioral Neuroscience, European Journal of Neuroscience, NeuroImage, Journal of Cognitive Neuroscience, NeuroComputing, Neuropsychopharmacology, Proceedings of National Science, The Anatomical Record, Neural Computation, PLoS ONE 雜志的審稿人。

李健博士的研究主要集中于人類(lèi)與獎(jiǎng)賞信息相關(guān)的學(xué)習(xí)和對(duì)應(yīng)決策的認(rèn)知神經(jīng)機(jī)制的研究。其早期的工作證明了紋狀體作為多巴胺神經(jīng)元的主要投射區(qū)域在以獲得獎(jiǎng)賞最大化的情境中所承擔(dān)的具體功能,紋狀體的活動(dòng)和被試動(dòng)態(tài)調(diào)整決策實(shí)現(xiàn)利益最大化的過(guò)程呈顯著的相關(guān)。李健博士的工作擴(kuò)展了多巴胺獎(jiǎng)賞通路的適用范圍,即多巴胺環(huán)路和其具體的計(jì)算功能不僅僅局限于初級(jí)(如食物,水,性活動(dòng))和次級(jí)(如金錢(qián))強(qiáng)化物,同樣的機(jī)理同樣適用于其他模態(tài)的強(qiáng)化物(如嬰兒的微笑,社會(huì)其他群體的信任,藝術(shù)品的美感等)。提供了有力的證據(jù)支持不同模態(tài)的獎(jiǎng)賞信息都與大腦多巴胺環(huán)路活動(dòng)關(guān)系密切;個(gè)體對(duì)于這些多模態(tài)獎(jiǎng)賞信息的過(guò)度依賴(lài)甚至成癮和多巴胺環(huán)路活動(dòng)的紊亂有直接的聯(lián)系。李健博士近年來(lái)的工作集中于理解大腦其他參與關(guān)于獎(jiǎng)賞學(xué)習(xí)和決策的腦區(qū)如何和紋狀體協(xié)同作用提高學(xué)習(xí)效率。同時(shí),他也關(guān)注社會(huì)信息如何干預(yù)和影響大腦中獎(jiǎng)賞/多巴胺通路的活動(dòng)從而影響個(gè)體的價(jià)值決策;這些工作對(duì)如何設(shè)計(jì)有效的干預(yù)手段調(diào)節(jié)人腦對(duì)于強(qiáng)化學(xué)習(xí)的依賴(lài)程度提供了具體的理論指導(dǎo)和實(shí)驗(yàn)數(shù)據(jù)支撐。

現(xiàn)主持的科研項(xiàng)目有:

國(guó)家自然科學(xué)基金委員會(huì)優(yōu)秀青年科學(xué)基金:認(rèn)知學(xué)習(xí)與價(jià)值決策

面上項(xiàng)目:不確定環(huán)境下強(qiáng)化學(xué)習(xí)和決策的神經(jīng)機(jī)制

科技部“青年973項(xiàng)目”:模型驅(qū)動(dòng)的獎(jiǎng)賞記憶相關(guān)腦區(qū)的功能整合研究

基金協(xié)作項(xiàng)目:非常規(guī)突發(fā)事件應(yīng)急管理基礎(chǔ)科學(xué)問(wèn)題與“情景-應(yīng)對(duì)”型總集成生化平臺(tái)研究

基金創(chuàng)新群體(協(xié)作項(xiàng)目):高級(jí)認(rèn)知的神經(jīng)和分子遺傳機(jī)理

英文論著

McClure, S.M.*, Li, J.*, Tomlin, D., Cypert, K.S., Montague, L.M. and Montague, P.R. (2004) Neural Correlates of Behavioral Preference for Culturally Familiar Drinks. Neuron, 44: 379-87.

Li, J.*, McClure, S.M.*, King-Casas, B. and Montague, P.R. (2006) Policy Adjustment in a Dynamic Economic Game. PLoS ONE 1(1): e103. *Authors contributed equally to the work.

Bogacz, R., McClure, S.M., Li, J., Cohen, J.D. and Montague, P.R. (2007) Short-term Memory Traces for Action Bias in Human Reinforcement Learning. Brain Research, 1153: 111-21.

Strathearn, L., Li, J., Fonagy, P. and Montague, P.R. (2008) What’s in a Smile? Maternal Brain Responses to Infant Facial Cues. Pediatrics, 122(1): 40-51.

Delgado, M.R., Li, J., Schiller, D. and Phelps, E.A. (2008) The Role of Striatum in Aversive Learning and Aversive Prediction Errors. Philosophical Transactions of The Royal Society B, 363(1511): 3787-3800.

Van den Bos, W., Li, J., Lau, T., Maskin, E., Cohen, J.D., Montague, P.R. and McClure, S.M. (2008) The Value of Victory: Social Origins of the Winner’s Curse in Common Value Auctions. Judgment and Decision Making 3: 483-492.

Li, J., Xiao, E., Houser, D. and Montague, P.R. (2009) Neural Response to Sanction Threats in Two- Party Economic Exchange. PNAS 106:16835-16840.

Dickerson, K.C., Li, J., Delgado, M.R. (2011) Parallel Contributions of Distinct Human Memory Systems During Probabilistic Learning. NeuroImage 55(1): 266-276.

Li, J., Delgado, M.R., Phelps, E.A. (2011) How Instructed Knowledge Modulates the Neural Systems of Reward Learning. PNAS 108(1): 55-60.

Li, J., Daw, D. (2011) Signals in Human Striatum are appropriate for Policy Update Rather Than Value Prediction. Journal of Neuroscience 31(14): 5504-5511.

Li, J., Schiller, D., Schoenbaum, G., Phelps, E.A. and Daw, D. (2011) Differential Roles of Human Striatum and Amygdala in Associative Learning. Nature Neuroscience 14(10): 1250-1252.

Jones, R.M., Somerville, L.H., Li, J., and Casey, B.J. (2011) Behavioral and Neural Properties of Social Reinforcement Learning. Journal of Neuroscience 31(37): 13039-13045.

Roesch, M.R., Esber, G.R., Li, J., Daw, N.D. and Schoenbaum, G. (2012) Surprise! Neural Correlates Linking Pearce-Hall and Rescorla-Wagner. European Journal of Neuroscience 35: 1190-1200.

Kishida, K.T., Li, J., Schwind, J. and Montague, P.R. (2012) New Approaches to Investigating Social Gestures in Autism Spectrum Disorder. Journal of Neurodevelopmental disorders 4-14.

Sip, K.E., Carmel, D., Marchant, J.L., Li, J., Petrovic, P., Roepstorff, A., McGregor, W.B. and Frith, C.D. (2013) When Pinocchio’s Nose does not Grow: Belief Regarding Lie-detectability Modulates Production of Deception. Frontiers in Human Neuroscience 7:16. Doi: 10.3389/fnhum.2013.00016. Epub 2013 Feb 4.

Kubota, J.T., Li, J., Bar-David, E., Banaji, M.R. and Phelps, E.A. (2013) The Price of Racial Bias: Intergroup Negotiations in the Ultimatum Game. Psychological Science 24(12): 2498-2504.

Jones, R.M., Somerville, L.H., Li, J., Ruberry, E.J., Powers, A., Mehta, N., Dyke, J., Casey, B.J. (2014) Adolescent-specific patterns of behavior and neural activity during social reinforcement learning. Cognitive, Affective, & Behavioral Neuroscience 14(2): 683-97.

Kubota, J.T., Li, J., Bar-David, E., Banaji, M.R. and Phelps, E.A. (2015) All claims in the original article hold as stated: a response to arkes. Psychological Science 26(2): 246-8.