Speaker: 鄭晨光，天津大學教授
Time: 2023年3月22日14點
Venue: 北京大學呂志和樓315會議室
Abstract: Spatiotemporal trajectories are coded by ‘‘theta sequences,’’ ordered series of hippocampal place cell spikes that reflect the order of behavioral experiences. Theta sequences are thought to be organized by co-occurring gamma rhythms. We found that slow gamma-associated theta sequences activated on a compressed timescale and represented relatively long paths extending ahead of the current location. Fast gamma-associated theta sequences more closely followed an animal’s actual location in real time. We further investigated whether such coordination of hippocampal place cell sequences by theta or sharp wave-ripples is disrupted during error trials in a delayed match-to-place task. Less compressed paths were represented on error trials as an incorrect stop location was approached. During rest periods of correct but not error trials, place cell sequences developed a bias to replay representations of paths ending at the correct reward location. These results support the hypothesis that coordination of place cell sequences by theta rhythms and sharp wave-ripples develops as a reward location is learned and may be important for the successful performance of a spatial memory task.
Bio: 鄭晨光，2013年畢業(yè)于南開大學計算神經(jīng)生理實驗室獲博士學位。2013-2018年期間在美國UT Austin學習記憶中心執(zhí)行主任Laura Colgin課題組從事博士后研究，2018年回國至今任天津大學精密儀器與光電子工程學院生物醫(yī)學工程系教授，博士生導師，天津市腦科學與神經(jīng)工程重點實驗室常務副主任。被中國工程院授予“中國工程前沿杰出青年學者”稱號，入選天津市高層次人才計劃、天津市創(chuàng)新人才推進計劃青年科技優(yōu)秀人才?？蒲泄ぷ骶劢褂诮獯a大腦神經(jīng)網(wǎng)絡中復雜的放電活動，以揭示多種認知行為的重要神經(jīng)機制。主持多項國家級、科技部及天津市級科研項目，在Neuron、Nature Communications等期刊發(fā)表論文30篇，參與撰寫神經(jīng)科學類書籍2部。 個人主頁：http://jyxy.tju.edu.cn/cn/szdw/20181027/1731.shtml
Host: 吳思
2023-03-13